Episode 2 of My Lady Jane commences with Lady Jane Grey laid out on Dr. Butts' examination table, as he endeavors to diagnose whether she suffers from the same affliction as King Edward. Realizing there's no escape, Jane abandons her facade and heads to the church, where she ties the knot with Lord Guildford Dudley.
At the wedding reception, Jane and Guildford argue over trifles, their words colliding like daggers. Lady Frances and Lord Dudley coerce their children to maintain a semblance of civility, awaiting the bedding ceremony later that evening. Guildford's brother, Stan, attempts to charm Lady Frances, his smooth words seemingly captivating the middle-aged woman. Dudley raises a toast to the newlyweds, and Bess sends her heartfelt wishes on behalf of King Edward.
Meanwhile, within the palace walls, Lady Mary and Lord Seymour tend to a feigning Edward. Once they depart, Petunia transforms into a human, her nostrils detecting the scent of poison. She advises Edward to sneak into the market, seeking the vendor who sold the poison, to uncover the culprit. Petunia entreats Edward to promise that once the perpetrator is punished, he will visit his grandmother.
Jane struggles to conceal her fascination with Guildford. Her youngest sister mischievously forces Jane and Guildford into an awkward kiss, igniting cheers from the wedding guests. Guildford spins Jane around, leaning in for a kiss but retreating at the last moment, leaving Jane dangling.
Amidst the festivities, Jane spots an Ethian attempting to pilfer silver coins. She follows him, inquiring about Susannah, but the man claims ignorance before fleeing. Finally, Jane and Guildford prepare for the bedding ceremony, the maids gently undressing Jane while Lady Frances whispers advice on how to navigate the male anatomy.On the contrary, Lord Dudley imparted a pressing urgency to Guildford, urging him to finalize the marriage with Jane at the earliest, for the future of their family hinged heavily on this union. As the wedding guests gathered, their eyes twinkled with anticipation, watching Jane and Guildford beneath the blanket, engaging in a playful leg wrestle, all for the amusement of the crowd. Soon, the revelry subsided, and the guests departed, leaving the newlyweds to their privacy.
However, this privacy was soon shattered by a heated argument. Guildford, adopting a lordly tone, commanded Jane to follow his lead, an act that sparked a furious reaction in her. In a fit of anger, Jane hurled wine at Guildford's face, staining his attire. She was then trapped inside the dressing room, while Guildford abandoned her, locking the door behind him. A maid appeared like a beacon of hope, unlocking the door and freeing Jane from her confinement.
Meanwhile, Frances embarked on a seductive journey with Stan, utilizing him as a means to uncover the financial truth of the Dudley family. Stan confessed, revealing that Lord Dudley was financially insolvent and had only accepted the proposal due to Jane's royal connection as a cousin of King Edward. Elsewhere, Mary and Seymour shared a tender moment, with him asking her to be patient until she ascended to the throne. Seymour proffered a ring to Mary, but she chose the one given by her father, King Henry.
Later that night, Jane summoned the maid once again, requesting her to unlock the dressing room door. Her thoughts wandered to Guildford, and she inquired about his whereabouts, learning that he had retreated to the stables. Jane hastened to the stables, where she found Guildford, stark naked, beneath a cascade of water. She stared at him, her gaze a mix of curiosity and anger, for she was still aggrieved by his earlier abandonment.
As she was about to unleash her indignation, Guildford underwent a startling transformation, morphing into a horse. Jane was left stunned, her mouth agape in disbelief. Lord Dudley then appeared, informing Jane that Guildford was indeed an Ethian, one who lost control of his form, transforming into a horse from sunrise to sunset. Jane was bewildered by this revelation, and even more so when Lord Dudley announced that she was destined for a honeymoon ride with Guildford, now in his equine form.
Jane solemnly informs him that she would never remain wedded to an Ethian, yet Lord Dudley gravely declares that the consequence of an Ethian-Verity union is nothing less than death. With her hands tied, Jane resigns to conceal this secret from all.
Elsewhere, Edward and Petunia embark on a stroll through the bustling local market, only to discover that he has been surreptitiously poisoned with a potent substance called Tofana. Deeply agitated, Edward rushes to meet Jane, demanding answers about the poison. Jane gravely reveals that Tofana is among the deadliest poisons, slowly infiltrating one's lungs and bloodstream even in minute doses. This revelation ignites a heated argument between the two, as Jane struggles to grapple with her marriage to an Ethian.
Jane returns to the Dudley palace, while Edward hurries to the royal palace to alert his subjects of the sinister plot. With stern determination, Seymour and Dudley swear to uncover the perpetrator at any cost, yet Edward dismisses them, his mind already made up. Meanwhile, Seymour urgently informs Mary that the king's suspicions have been aroused, forcing her to take command of the situation.
Worried that his throne is in peril, Dudley dispatches Stanley to retrieve the King's will. As Jane embarks on her honeymoon, she intends to steal the wedding gifts and flee, but is astonished to find that they have been swapped with tomes on various medicinal herbs. This unexpected discovery leaves her surprised, learning that Guildford also harbors a passion for medicinal texts.
Alternately, Stanley encounters Frances and discloses that King Edward's will has vanished into thin air. As the scene unfolds, Seymour, Mary, Bess, and Dudley make a dramatic entrance into Edward's chamber, proclaiming Dudley as the culprit behind the poisoning. Dudley struggles to clear his name, but Seymour cunningly plants a packet of Tofana in the counselor's pocket, accusing him of attempting to poison the king in order to pave the way for Jane to ascend to the throne.
Promptly, Edward orders Dudley's arrest, unaware that Mary is once again attempting to poison him, causing him to slip into unconsciousness. It is then that Edward notices Seymour's ring adorning Mary's neck, and a realization dawns that she is the true perpetrator.
As the night deepens, Guildford returns to his human form, confessing to Jane that he would consider a divorce if she could assist him in finding a cure for his daily transformation into an Ethian. Jane agrees, expressing her desire for independence and freedom. Guildford escorts Jane to her chamber, reassuring her that their union need not be bound by marital duties, yet their attraction remains undeniable.
The episode culminates in Edward escaping from the concealed chamber where Mary and Seymour had imprisoned him. Left to speculate, Seymour and Mary presume that Edward had fallen from the window in a desperate bid for freedom, concluding that the King had indeed perished.
