The second episode of Mrs. Deshpande commences with a poignant flashback to the Hyderabad prison, where our protagoness found herself incarcerated. There, a fellow inmate served as a conduit, facilitating the exchange of letters with Hosh, becoming their means of communication amidst the confines of their respective cells. In these letters, Hosh penned his dark desires, detailing the many enemies he sought to silence, while Mrs. Deshpande, in her own way, lent encouragement.

Fast forward to the present, Tejas grills Mrs. Deshpande over these letters, accusing her of fostering Hosh's murderous intentions. She counters, claiming Hosh's threats to expose her secrets compelled her responses, insisting he was a cowardly talker with little substance. Arun urges Mrs. Deshpande to take action, suggesting they meet Hosh in person to unravel the truth behind the murders.
Tejas proposes the use of harsh interrogation techniques, but Arun counters that such tactics would be ineffective on Mrs. Deshpande's resilient spirit. Meanwhile, Hosh is poised to choke his latest hostage, Jatin, adding another grim chapter to the string of strangulation murders.
Inspector Poonam Sonawane, in a private meeting with Arun, reveals a chilling revelation: all the strangulation murders are interconnected, and the killer employs a local glue to keep the victims' eyes open. She offers her assistance, but Arun requests she remain discreet until they gain further insights into the crime.
Mrs. Deshpande rereads the letters with newfound insight, realizing Hosh had briefly ceased writing to her earlier that year. Using Inspector Omkar's phone, she calls Tejas, disclosing Hosh's struggles making friends and assuming he may have stopped writing due to a recent betrayal by one of them. Tejas embarks on a hunt for Hosh's friend, interrogating his uncle, Jehan, who reveals Hosh's brief stint at a construction company. The trail leads them to Jatin, a friend who has been missing for several days and whose disappearance now looms as a crucial piece in the puzzle of Hosh's motivations.
As the police set out on their hunt for Jatin, they stumbled upon a shocking revelation: the man was holed up in a picturesque hill station with his family. Ignorant of the sinister plan unfolding within, they raided Jatin's home. Little did they know, Hosh had taken Jatin's wife and daughter hostage within its walls, his knife poised to strike. Tejas, with a swiftness born of instinct, disarmed Hosh and arrested him, saving the family from harm. But Jatin was nowhere to be found.
Back in Mumbai, Hosh found himself in the police's grasp, and Tejas questioned him relentlessly about the letters and his role in the murders. Hosh, in a bid to secure a meeting with Mrs. Deshpande, offered to reveal Jatin's whereabouts. The police escorted him to her abode, their conversation carefully monitored.
As they spoke, Mrs. Deshpande delved deeper, pressing Hosh for details about the murders. But Hosh faltered, unable to articulate the gruesome details. She called his bluff, declaring him a coward incapable of taking a life. Enraged by her words, Hosh vowed to keep Mrs. Deshpande's secrets safe. Her ire left him trembling in fear. In a desperate attempt to atone, he revealed Jatin's location, and the cops raced to save him.
But before they could leave, Mrs. Deshpande whispered something into Hosh's ear that the cops couldn't hear. Instantly, Hosh broke down, weeping loudly before collapsing to the ground. Tejas burst into the room as Hosh was being taken to the hospital, his fury palpable.
"What did she whisper?" Tejas demanded, his voice low and fierce. Mrs. Deshpande revealed that Hosh was not the copycat killer but that the real culprit was already on the prowl for their next victim. And sure enough, the killer followed a drunk middle-aged man down the streets, who eventually got into his car and drove away into the night.
The dawn arrived, and Tejas made his way to Mrs. Deshpande's doorstep, bearing gratitude for her pivotal role in rescuing Jatin. She welcomed him with a meal brimming with her culinary prowess, and the duo engaged in a lively discourse on the intricacies of good and evil. As they chatted, Mrs. Deshpande inquired about Tejas' familial ties, learning of his early loss of parents and the resilience he's forged from it. He shared stories of his wife, Tanvi, and their esteemed grandfather, each name held with a weight of affection.
Tejas instructed the cyber team to sift through the audio from the hushed exchange between Hosh and Mrs. Deshpande, seeking clues that might unravel the mystery further. Meanwhile, the doctor updated Tejas on Hosh's condition—unpredictable but gradually improving.
That evening, Tejas, Tanvi, and their friend Divya gathered to celebrate their grandfather's birthday. Their laughter and banter danced around the room, as they playfully speculated on the possibility of Tejas and Tanvi starting a family. However, Tanvi's firm rejection of the idea added a note of seriousness to their playful conversation.
Meanwhile, Mrs. Deshpande found herself engaged in light-hearted banter with the police officer on duty, her efforts to make small talk a testament to her innate warmth and curiosity. In a separate corner of the city, the killer made a return visit to the same individual they had targeted earlier in the night, closing another chapter in the story as the episode drew to a close.