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According to reports from TMZ, the 54-year-old actress was admitted to the hospital in late March, though the details surrounding her hospitalization remain hazy. It's also uncertain whether this stay is directly related to her multiple sclerosis diagnosis, which she first disclosed in 2021. Although her team has not confirmed specifics, a representative hinted that Applegate has "a long history of complicated medical conditions that she has been refreshingly open about, as evidenced in her memoir and on her podcast."

This openness has been particularly evident in recent weeks. The Dead to Me star released her memoir, "You With the Sad Eyes," where she shared a candid glimpse into her daily life with MS. "When I wake up, I often can't move my arm far enough to grab the cup of water by my bed or my phone from its charger," she wrote.
Applegate has also been candid about the emotional weight that comes with her diagnosis. In a recent podcast appearance on NPR's Wild Card With Rachel Martin, she admitted that she thinks about death "every day because it's looming," explaining that "it looms for all of us."
"For people who have a disease like this, you never know, do you?" she added, revealing that she has already made arrangements for her future, including purchasing burial plots.
Despite these challenges, Applegate has continued to stay active professionally. Her memoir has been well received, even earning praise from former co-star Chevy Chase, who called her incredibly talented.
At this time, representatives for Applegate have not responded to Parade's request for comment.