As the second chapter of "Doc" unfolds, a woman embarks on a romantic encounter, sharing the intricacies of her profession with her companion. However, her demeanor quickly sours. As she rises to her feet, her gaze appears to alight upon her daughter, Gracie, in the vicinity, though she is but a figment of her imagination. Soon after, Simone's ex approaches her, spouting words of resentment for her departure. Overwhelmed, Simone (played by Alexandra Castillo) collapses.
At the hospital, Sammy arrives with an array of files for Amy Larsen (Molly Parker). Simone is rushed in and placed in Larsen's room. Dr. Jake Heller (portrayed by Jon-Michael Ecker) enters the scene, his eyes locking onto Amy, instantly transporting him back to their past relationship. Jake reassures Simone that they will unravel the mystery of her condition. Larsen, sensing a lupus flare-up in Simone, voices her suspicion, but Jake firmly refuses to discuss one patient with another, sternly asking Amy to refrain from interfering.
Amy seeks counsel from Dr. Michael Hamda (Omar Metwally) regarding her chances of returning to practice. Michael cautions against such discussions, noting that it has been mere days since the incident. Meanwhile, Dr. Richard Miller (Scott Wolf) consoles his colleagues, expressing the collective shock and praying for Dr. Larsen. He receives a call from Marcia Wortham (Dale Boyer), and their conversation delves into the Dixon case. Richard admits his predicament if the autopsy reveals Metoprolol in Dixon's system. Marcia reminds him that Larsen was the sole witness, now void of recollection. She urges Richard to obtain the autopsy results and inform her promptly.
Sonya Maitra (Anya Banerjee) engages Jake, explaining the rationale behind her complaints against her supervisor. Jake adheres to the unwritten rule of not betraying one's colleagues, but Sonya insists that Larsen fostered a toxic workplace. Amy, attempting to gather insights into Simone's plight, is gently steered away by Sonya, who cautions her to tread carefully around the patients.
During Simone's MRI, Amy finds a moment to reminisce with Dr. Gina Walker (Amirah Vann) about a concert they once attended, a memory that brings a smile to both their faces. Sonya grants them a brief respite, allowing them some privacy. Seizing the opportunity, Amy inquiries if Gina could intercede with Michael to facilitate her return to work.
Gina hesitates to nurture false aspirations in Amy's heart. Seven years prior, Amy confided in Gina, revealing she had informed Michael of her desire for solitude. Gina responds, noting that six days have already passed, urging Amy to cease her evasion. Amy, reluctant to venture beyond the sanctuary of her room—where Danny's memory still lingers warmly—is gently reminded by Gina of her daughter and awaiting patients who depend on her expertise.
At the hospital, Amy collaborates alongside Dr. Richard Miller, who expresses his condolences and offers unwavering support. He volunteers to shoulder her responsibilities should she require extra time at home. However, Amy requests silence from him, her mind elsewhere.
In the present moment, Amy halts her stride to embrace Richard, congratulating him on his ascension to the position of chief. Her daughter, Katie (Charlotte Fountain-Jardim), appears, informing her of a brief visit due to her upcoming history class. Katie shares that her mother had discouraged her from pursuing medicine, yet promises a visit the following day. Noticing an unspoken burden, Amy inquiries if all is well, to which Katie replies cryptically, hinting at numerous occurrences left untold. She departs abruptly, leaving Amy with more questions than answers.
Meanwhile, Jake attends to Simone as Amy lends assistance nearby, focusing on sourcing compatible blood for a transfusion. Jake teases Simone about seeking a second opinion, lightening the tense atmosphere. Elsewhere, Richard and Michael discuss Amy's situation among board members. Amy enters the room, engaging Max Garner (Darrin Baker), now the CEO, about her future and her intent to return to work. Max suggests it might be premature, prompting Richard to share his thoughts. He admits the unpredictability of her future capabilities. Michael believes researching similar cases could be beneficial. Amy proposes examples: Doctor Jeff Grenis from Dallas and Dr. Nina Richman in Tulsa. Dr. Lisa Kumara (Imali Perera) expresses discomfort with Amy's abrupt intrusion, prompting Max to suggest further deliberation is needed.
Returning to her room, Amy is introduced to Grace, unaware of her mother's lupus battle. Amy gently explains the autoimmune flares, where the body turns against itself, painting a vivid picture of her ongoing struggle.