The narrative of "Invincible" Season 2 Episode 5 picks up with Mark, his gaze fixed upon the devastated ruins of the Thraxan city, an image so harrowing it sends him into a faint. Meanwhile, Andressa and Mark's half-brother remain unharmed, and Mark lends a hand in the arduous task of reconstruction. Andressa, whose aging accelerates rapidly, places a poignant request in Mark's hands: to escort his brother back to Earth.
Upon their return, Earth finds Debbie resuming her professional duties with renewed vigor. Mark, after an absence of two months accompanied by his infant brother, steps back into his family home. Debbie, sensing the need, steps forward to shoulder the responsibility of caring for the baby, thereby enabling Mark to continue his college education uninterrupted. Elsewhere, Donald confronts Cecil about his transformation into a superhuman cyborg, prompting Cecil to confess the truth and assure Donald of his improved state.
Mark reenters the realm of academia, only to be confronted by a distressed Cecil who had been deeply perturbed by Mark's prolonged absence. During Mark's hiatus, the Guardians had narrowly escaped defeat. Now, Cecil harbors plans to whisk Mark's brother away to safety.
Elsewhere, Mark reconnects with Amber, their bond undiminished by time. Suddenly, Cecil interjects with grave news: Martians are en route to Earth. An astonishing revelation unfolds as it transpires that the Guardians are already aware of Shapesmith's Martian origins. Shapesmith, unable to conceal the truth any longer, confesses to murdering the human astronaut to facilitate his arrival on Earth. Moreover, they now face the impending threat of the Sequids.
Eve, burdened by guilt after an accidental injury to civilians in a battle, returns home to find Rex offering comfort and seeking her assistance. Cecil appeals to Mark for his help in thwarting the Sequids. As most of the Guardians depart for the mission, King Lizard strikes a military base, and the Martians sabotage a space shuttle. In a daring maneuver, Atom Eve phases the Martian ship into existence, confrontation looming large.
Rex, Dupli-Kate, and Shrinking Rae bravely confront King Lizard and his formidable combatants, while the remainder of the Guardians wage a fierce battle against the Sequids. Tragedy strikes as King Lizard's ruthless fighters mercilessly slay Rae and Kate in a scene of unspeakable horror. Despite his grief, Rex summons the strength to vanquish their assailants, yet finds himself kneeling powerless, bent, as King Lizard trains a cold gun barrel against the back of his skull.
In the poignant epilogue, Allen the Alien awakens from his slumber, a survivor of the devastating conflict with the Viltrumites, his powers augmented beyond imagination. To his astonishment, he discovers that Thaedus stands as the solitary Viltrumite defiant against the Empire's tyranny. With a mission of monumental importance, Thaedus bestows upon Allen the crucial task of enlisting Invincible in their rebellion.